Close Menu
  • Business
  • Technology
  • Gadgets
  • Digital Marketing
  • Social Media
  • Health
  • Lifestyle
  • Gaming
Facebook X (Twitter) Instagram
Tech Remarkable
  • Business
  • Technology
  • Gadgets
  • Digital Marketing
  • Social Media
  • Health
  • Lifestyle
  • Gaming
Tech Remarkable
Home » Synthesis of Jones Reagent
Main

Synthesis of Jones Reagent

Ethan FrankBy Ethan FrankFebruary 6, 2023No Comments1 Min Read
Jones Reagent
Jones Reagent

Synthesis of Jones Reagent

Jones Reagent: 7-[2-Methoxyimino-2-{2-(2,2,2-trifluoroacetamido)-1,3-thiazol-4-yl}acetamido]-3-hydroxymethyl-3-cephem-4-carboxylic acid (syn isomer) (1.0 g.) was dissolved in a mixture of dimethylformamide (6 ml.) and acetone (30 ml.).

Jones reagent (1.25 ml.), which was prepared from conc. sulfuric acid (0.28 ml.), chromium trioxide (0.33 g.) and water (0.9 ml.), was dropwise added thereto over 2 minutes with stirring and cooling at 0° to 2° C. After stirring for 20 minutes at the same temperature, the reaction mixture was poured into ice-water (50 ml.).

After acetone was distilled off, the residue was twice extracted with ethyl acetate (50 ml.). The extracts were washed with a saturated aqueous solution of sodium chloride and dried over magensium sulfate. The solvent was distilled off and the residue was pulverized with diisopropyl ether to give 7-[2-methoxyimino-2-{2-(2,2,2-trifluoroacetamido)-1,3-thiazol-4-yl}-acetamido]-3-formyl-3-cephem-4-carboxylic acid (syn isomer) [or this compound can be represented as 3-hydroxy-6-[2-methoxyimino-2-{2-(2,2,2-trifluoroacetamido)-1,3-thiazol-4-yl}acetamido]-5a,6-dihydro-3H, 7H-azeto[2,1-b]furo[3,4-d][1,3]thiazine-1,7(4H)dione (syn isomer)] (0.56 g.)

Jones Reagent
Ethan Frank

Leave A Reply Cancel Reply

Latest Post

How to Handle Probate Disputes: Mediation and Legal Options

December 9, 2024

Protecting Our Children: The Importance of Child Custody Investigations

December 9, 2024

One of the greatest Relationship Software For 2024

August 3, 2024

Gloss Mail-order Brides: How To Find A Spouse Out of Poland? Simply by Rick Dawson

July 27, 2024

TechRemarkable

Embark on a journey of discovery through the intricate realm of cutting-edge innovation and digital wonders. Our tech website is your compass in the digital landscape, guiding you through the latest advancements, insights, and trends that shape the future. Contact us: [email protected]

Editor's Pick

Everything You Need to Know About Campervan Rental

August 17, 2023

How to Turn Low Data Mode Off

February 6, 2023

How to Share MTN Data With Another Number

February 6, 2023

Subscribe to Updates

Get the latest creative news from Techremarkable about Technology, Business. Health, Gaming & LifeStyle etc.

© 2025 Tech Remarkable. All rights reserved.
  • About Us
  • Contact Us
  • Privacy Policy
  • Terms & conditions

Type above and press Enter to search. Press Esc to cancel.